HomeNewsCannabis Compound Shows Promise In Treating Childhood Epilepsy

Cannabis Compound Shows Promise In Treating Childhood Epilepsy

Further evidence has emerged that cannabidiol (CBD),  a compound in cannabis, can be effective in treating epilepsy in children.

The evidence was presented at the American Epilepsy Society Annual Meeting early this week.

Epidiolex, based on CBD, was administered in addition to the normal regime of anti-epileptic drugs (AEDs) taken by 261 patients enrolled in a special program. Most of the participants were children, with a median age of 11.8 years.

A median reduction in total seizures of 45% was observed across all patients after 12 weeks of treatment, and maintenance of clinical effect was present at 36 weeks.

47% of the patients involved experienced a reduction in seizures after 12 weeks treatment of more than 50%.

4% reported an adverse event leading to discontinuation of Epidiolex and 12% withdrew from the program due to lack of clinical effect.

Serious adverse events were reported in 106 patients, but only in 5% were the incidents deemed possibly related to the Epidiolex treatment.

“These data reinforce and support the safety and efficacy we have shared in previous studies. Most importantly it is providing hope to the children and their families who have been living with debilitating seizures,” said lead author Orrin Devinsky, M.D., of New York University Langone Medical Center’s Comprehensive Epilepsy Center.

Dr Devinsky stressed the results are from an uncontrolled study; but that randomized controlled studies are now underway – the results of which will be available next year .

Epidiolex is produced by GW Pharmaceuticals and consists of 98 percent purified cannabidiol. GW Pharmaceuticals grows its own medical-grade cannabis at an undisclosed location in the South of England.

In a very limited 2013 study of the effectiveness of cannabidiol, 84% of the 19 parents involved reported a reduction in seizure frequency while their child was taking CBD.  Eight reported a greater than 80% reduction in seizure frequency.

6.3 per 1000 children are diagnosed with epilepsy and specialists estimate up to 20% of these cases show some degree of drug-resistance – so the potential for benefit through the use of CBD is huge.

Cannabidiol is one of dozens of active cannabinoids identified in cannabis. It constitutes up to 40% of the plant’s extract in medicinal cannabis strains and up to 1% in some strains of industrial hemp.

Cannabidiol does not induce a “high”.

In related news, in the Australian state of Victoria, the government yesterday introduced legislation into Parliament that will enable access to medicinal cannabis in exceptional circumstances. Among the first expected to benefit are children with epilepsy.

Steven Gothrinet
Steven Gothrinet has been part of the Hemp Gazette in-house reporting team since 2015. Steven's broad interest in cannabis was initially fueled by the realisation of industrial hemp's versatility across multiple sectors. You can contact Steve here.

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